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Colivelin Syn-60232

Product Name  
Colivelin
 
Catalog Syn-60232
Sequence
(One-Letter Code)
SALLRSIPAPAGASRLLLLTGEIDLP
Sequence
(Three-Letter Code)
H - Ser - Ala - Leu - Leu - Arg - Ser - Ile - Pro - Ala - Pro - Ala - Gly - Ala - Ser - Arg - Leu - Leu - Leu - Leu - Thr - Gly - Glu - Ile - Asp - Leu - Pro - OH
Molecular Weight 2645.1
Description This hybrid peptide named colivelin was synthesized to potentiate the neuroprotective effect of humanin (HN). Colivelin is composed of Activity-Dependent Neurotrophic Factor (ADNF) C-terminally fused to AGA-(C8R) HNG17, a potent HN derivative. Colivelin completely suppresses cell death induced by overexpressed Familial Alzheimer's disease (FAD)-causative genes and beta-amyloid (1-43). Intraperitoneally administered colivelin suppresses memory impairment and might serve as a novel drug candidate for treatment of Alzheimer's disease.
Storage -20°C

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