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Peptide PEGylation and Biotin

1. Peptide PEGylation
PEGylation is the covalent conjugation of macromolecules (antibody, peptide, etc.) with polyethylene glycol (PEG), polymers that are nonionic, nontoxic, biocompatible and highly hydrophilic. The PEGylated macromolecules have enhanced therapeutic properties due to their increased solubility (for hydrophobic drugs) and bioavailability, masked antigenicity for minimum immune response in host, prolonged circulatory time within host through reduced renal clearance.

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