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Glycopeptides and Glycated Peptides

Over the past few decades it has been recognised that glycans on cell surface (attached to membrane proteins or lipids) and those bound to proteins (glycoproteins) play a critical role in biology. For example, these constructs have been shown to play important roles infertilization, the immune systembrain development, the endocrine system and inflammation.
The synthesis of glycopeptides provides biological probes for researchers to elucidate glycan function in nature and products that have useful therapeutic and biotechnological applications.                                    
Glycopeptide Linkage Variety   

·N-Linked Glycans
N-linked glycans derive their name from the fact that the glycan is attached to an asparagine (Asn, N) residue,and are amongst the most common linkages found in nature. Although the majority of N-linked glycans take the form GlcNAc-β-Asn other less common structural linkages such as GlcNac-α-Asn and Glc-Asn have been observed.

·O-Linked Glycans
O-Linked glycans are formed by a linkage between an amino acid hydroxyl side chain (usually from serine or threonine) with the glycan. The majority of O-linked glycans take the form GlcNac-β-Ser/Thr or GalNac-α-Ser/Thr.
 Glycopeptides containing monosaccharides
Ser/Thr(GlcNAc), Ser/Thr(GalNAc), Asn(GlcNAc), Ser(Xyl), Thr(Man), etc                      
Glycopeptide and Phosphopeptides                                             
The glycopeptide that SynPeptide successfully synthesized

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