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Cyclic Peptides and Branched Peptides

Constraints by cyclization at either the backbone or side chain of the peptide are expected to reinforce and enhance the stability of the 3D-structure, such as α-helix, as well as the increment of the resistance to the enzymatic digestion.

Cyclized Peptides
cyclo(X1-X2——–Xn)
Head-to-tail cyclization

 
X = NH : polypeptide
X = O : depsipeptide
(including N-methyl amino acids)
Diketopiperazine
 
R=H : cyclo(X-Pro)
R=OH : cyclo(X-Hyp)
 
cyclo(X-X)
Staple peptide
 
site-specific ligation using olefin metathesis
Cyclization at side chain
 
Lactone/Thiolactone
 
X=O : lactone
X=S : thiolactone
Thioether
 
Deamino-dicarba

[Asu 1,6]-Oxytocin
(Deamino-Dicarba-Oxytocin)
 
Oxytocin
Branched Peptides(Isopeptides)
Branched at Asp/Glu
 
n=1 : Asp
n=2 : Glu
 
Branched at Lys
 
Branched at Ser/Thr

 
X=H : Ser
X=CH3 : Thr
We have lots of successful syntheses of the cyclic peptides as well as the branched peptides.
Please contact us for additional information or send an email to peptide@synpeptide.com 
To contact us by phone, please call 0086-21-50835580
 

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